Nine months into the global pandemic, scientists are still piecing together the mystery of the first crossover event, in which the coronavirus moved from bats to an intermediary animal, and eventually, to humans. Why Did UK Regulators Beat the FDA to Approving Pfizer's COVID Vaccine? “It is not random that a lot of these viruses are coming from bats. If there's a nasty virus out there waiting to infect humans, there's a good chance that a bat carries it. Inovio Pharmaceuticals said last month that the FDA had accepted its vaccine candidate, INO-4800, setting the stage for phase 1 human trials. A bat’s antiviral defenses let it safely carry viruses that can cause deadly outbreaks in other animals. Dr. Alex Berezow is a PhD microbiologist, science writer, and public speaker who specializes in the debunking of junk science for the American Council on Science and Health. Should You Worry About Artificial Sweeteners? 9/11 Truther Mark Ruffalo Testifies to Congress on Science, Nothing Grimes Said About Eyeballs or Depression Makes Any Sense, Jeff Bezos' Plan to Colonize Space is Based on Sheer Nonsense, Robert F. Kennedy, Jr. is Helping Spread Flu and Cervical Cancer, Anti-Monsanto Lawyer and USRTK, Carey Gillam Collaborator Possibly Headed to Prison for Extortion, Journalist Peter Fairley Cites Anti-Vaxx Website, Spreads Misinformation on Flu, COVID-19, DeSmogBlog: Climate Website Is Headed by Anti-Vaxxer Brendan DeMelle, DeSmogBlog: Climate Activist Site Smears Freeman Dyson and Other Scientists. ", "At least nine more bat viruses are poised to infect humans," Stephen Barker, a Jefferies analyst, said in a note. Why is it that many of the viruses that severely affect other mammals, including humans, are apparently less pathogenic for bats. For instance, they are the only mammals that can fly. Agreement with Others, Correspondence to Reality, or Mere Opinion? A dead host is literally a dead end for a virus, so a virus wants to hit the "sweet spot" where it can reproduce as much as possible without killing the host too quickly or making him too sick to spread it around. COPYRIGHT © 1978-2020 BY THE AMERICAN COUNCIL ON SCIENCE AND HEALTH. DOI: 10.1007/s13752-020-00363-6, Vice President of Scientific Communications. The trend would be dangerous for the economy and the financial markets, which suffered the fastest bear market in March during the current pandemic, but it could leave one bright spot for investors to bet on — biotech companies. The new coronavirus, which has traversed the globe to infect more than 1 million people, began like so many pandemics and outbreaks before: inside … More bat viruses are coming so buy these biotechs, Jefferies says. Gilead CEO said on Sunday the drug will be in the hands of doctors and patients as early as this week. Pfizer, Roche and Novartis are also involved in the development and production of potential Covid-19 remedies. Microsoft may earn an Affiliate Commission if you purchase something through recommended links in this article. Such incredible density favors the evolution of virulent viruses. The Next COVID: Should We Fear the Global Spread of H5N8 Bird Flu? A paper by Frans Roes in the journal Biological Theory attempts to answer this seemingly simple question. The answer depends not just on the nature of the microbe but on the genetics of the individual. Connect with friends faster than ever with the new Facebook app. Are "Low Dose" Health Effects of Chemicals Real? Therefore, in order to answer it, Roes breaks down the big question into three smaller questions: The first question is one of the most difficult in all of medical microbiology. The final question is a bit paradoxical. Here's What to Do, one of the most difficult in all of medical microbiology, 'Stay Home, Stay Safe': The Clarion Call of Head-in-the-Sand Hypocrites. Coronavirus. Here's the murky origin story of the novel coronavirus. Bat viruses are shed through urine, feces and saliva. Even if a bat is too sick to move, the proximity of so many other bats means that others will become infected, no matter how deadly the virus is. Like us on Facebook to see similar stories, US coronavirus: FDA's Covid-19 vaccine authorization is a 'monumental moment,' expert says. Other research has shown the virus to be 96 per cent identical to a previously identified bat coronavirus, with a common ancestor about 50 years ago. Source: Roes FL. The coronavirus was first identified in Wuhan, China, more than four months ago. Despite the pandemic, the global trade … They are the natural reservoir for the Marburg virus, and Nipah and Hendra viruses, which have caused human disease and … COVID: Why Do So Many Nasty Viruses Come from Bats? [5] Although the bat viruses are more similar to human SARS-CoV-2 than the pangolin viruses, there are several reasons why the pangolin link is receiving special attention. The World Health Organization is launching a new mission to locate the origin of the coronavirus in China amid growing debate over the source of the outbreak. the same family of viruses that one that caused severe. Finally, bats' flight likely allows them to come into contact with more species than is typical for other mammals. Many deadly viruses that affect people are believed to have originated in bats, including rabies, Ebola and SARS -CoV-2, the strain that causes COVID-19. Perhaps flight, which increases body temperature, allows bats to fight off viruses easier than other mammals. Why are some infectious diseases more harmful than others? Israeli scientists go 'backward in time' by successfully reversing ageing by 25 years It’s more likely that the bat first gave the virus to another animal, which in turn passed it on to people, it wrote. TUESDAY, April 28, 2020 (HealthDay News) -- Bats and coronavirus have been evolving together for millions of years, researchers report. 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Dr Shi herself has been at the centre of a number of allegations and she was forced to deny that the virus may have come from her lab. In a new study, Boots and fellow researchers investigated virus infectivity on bat cell lines, including cultures from the Egyptian fruit bat (Rousettus aegyptiacus) and the Australian black flying fox (Pteropus alecto). The final question is a bit paradoxical. More recently strong genetic similarities have been found between SARS-CoV-2 and several viruses infecting Malayan pangolins (scaly anteaters). Bats are thought to be the natural host of the Ebola virus, rabies, SARS and MERS, with the latter two both coronaviruses similar to the one that's now emerged in Wuhan. The bat soup rumor is false. Several ideas have been put forward from natural-borne in bats, an escape from a lab in Wuhan and others. Don't Panic, Everything Goes to Pot: Myths Are Driving FDA, CDC Vaping Policy, What the Hulk? More than 1.2 million people in the U.S. have been infected by the coronavirus as of Wednesday, with the death toll climbing to 71,000, according to data from Johns Hopkins University. Roes tackles the question from a different angle: Transmissibility. Roes believes the answer to the second question involves the fact that bats often congregate in giant roosts, sometimes up to one million individuals at a density of 3,000 bats per square meter. One project will look at the interplay between genes and the immune response in humans, mice, and more than 30 species of bats, to determine how organisms might mount a … Citing research from Dr. Ralph Baric, Professor of the Departments of Epidemiology & Microbiology and Immunology at the University of North Carolina, Jefferies said there are nine potential SARS-like coronaviruses that could emerge from animals, with the ability to "enter and propagate within the epithelial cells that line human lungs. Scientists suspect COVID-19 originally came from a bat, which may have harbored a wide range of coronaviruses. (This story is for CNBC Pro subscribers only.). Coronavirus: Fear of a Pandemic, or a Pandemic of Fear? "All nine have demonstrated the ability … Considering the rate at which SARS-like bat viruses have been infecting humans, it seems likely that more viruses will emerge in the not-too-distant future.". We raise our funds each year primarily from individuals and foundations. ACSH does not have an endowment. Putting theory aside, one thing is for certain: There will be "another COVID" among humans, and there is a high likelihood that the guilty species will be a bat. Any of these viruses might be contagious to humans. Wuhan has said that there are more viruses coming so. Virologist Dr Shi Zheng-Li warned bats in China and South Asian countries are harbouring more viruses like the deadly Covid-19 that has already caused over 1.5m deaths worldwide How Toxic Terrorists Scare You With Science Terms, Adult Immunization: The Need for Enhanced Utilization, IARC Diesel Exhaust & Lung Cancer: An Analysis. Formerly, he was the founding editor of RealClearScience. Comparing COVID Vaccines: Pfizer vs. Moderna vs. AstraZeneca/Oxford, COVID Infection Fatality Rates by Sex and Age, Allergic Reactions to Pfizer's Vaccine Were Inevitable, and it's No One's Fault, Thank You, Trial Lawyers, For Protecting Us from the Scourge of Baby Powder. Furthermore, bats often share their homes with other bat species, which may favor the evolution of viruses that can jump to other species. A coronavirus that originated in Wuhan, China, has killed at least 170 people and infected more than 8,200. Perhaps bats have evolved immune systems that can handle virulent viruses. Rio Bravo virus, for instance, found among some California bats in 1954 and related to the yellow fever virus, was one. Shi Zhengli bat woman, who is a virology expert from. 95% of Baby Food Tainted with Toxic Metals? An acceleration of the adaption of animal viruses to humans — three cases in the past 20 years — has led scientists to believe more coronavirus-like diseases will be inevitable. Gilead Sciences' antiviral drug remdesivir had showed promising early results recently. Ebola. He is also an Analyst at Geopolitical Futures and a featured speaker for The Insight Bureau. In other words, a virus will evolve to become deadlier if it is still successful at infecting others. Learn more about the possible causes of the new coronavirus, as well as the role of bats in the spread of disease. While this may protect the bats from getting infected with high viral loads, it encourages these viruses to reproduce more quickly within a host before a defense can be mounted. to produce between 600 million and 900 million. Moderna said Thursday the Food and Drug Administration has approved its coronavirus vaccine candidate for phase 2 trial, adding it will begin the next round of trials with 600 participants shortly and is finalizing plans for a phase 3 trial as early as this summer. What Is Truth? In a new … Globally, more than 3.65 million cases have been confirmed and over 256,800 people have lost their lives. Johnson & Johnson said that it's aiming to produce between 600 million and 900 million doses of its own pending cure by the end of the first quarter of 2021 for emergency cases. Restated, if bats transmit so many nasty viruses, then why don't the bats get sick? Teflon and Human Health: Do the Charges Stick? Here, the answer is more speculative than for the other questions. Bats in the frontier regions of south and south-west China harbour other coronaviruses that already have the capacity to cross over to humans, a prominent Chinese scientist has said. This includes several from the genus Ledantevirus: Kern Canyon virus, which was found in the Yuma myotis in California (US); Kolente virus from the Jones's roundleaf bat in Guinea; Mount Elgon bat virus from the eloquent horseshoe bat in Kenya; Oita virus from the little Japanese horseshoe bat; and Fikirini virus from the striped leaf-nosed bat in Kenya. "The continuation of this trend may be disastrous for human health and the economy, but potentially lucrative for biopharma companies," Barker said. The Next Plague and How Science Will Stop It. He concludes that "the easier it is for a parasite to be transmitted from very sick hosts, the more virulent the parasite will be." Shares of Gilead have climbed 20% this year, compared to the S&P 500's 10% losses. Outbreaks of Nipah virus in Bangladesh have been linked with date palm sap collected from trees that bats had licked or … Dr Shi Zhengli of the Wuhan Institute of Virology said these viruses, including close relatives of Sars-CoV-2, which causes Covid-19, were likely to be circulating in […] It came on the deadliest day of the pandemic, GOP Congressman: We Need The Senate To Investigate Hunter Biden. A lot of effort is going into finding that “in between” animal, Weese said. According to scientists, the virus almost certainly came from bats. Furthermore, bats often share their homes with other bat species, which may favor the evolution of viruses that can jump to other species. As the hunt for a vaccine against the coronavirus continues around the world, health-care analysts at Jefferies warned more diseases from wild habitats are inevitable. “The bottom line is that bats are potentially special when it comes to hosting viruses,” said Mike Boots, a disease ecologist and UC Berkeley professor of integrative biology. The viruses that caused SARS, MERS, Ebola, Nipah, Hendra, and Marburg can all be traced back to bats, according to the UC Berkeley researchers, … It's a hard question with no obvious answer. Tacaribe virus, carried by both bats and mosquitoes in Trinidad, was another. Should You Worry About Artificial Flavors Or Colors? Why? Biol Theory 15: 223-225. Reclusive, nocturnal, numerous -- bats are a possible source of the coronavirus. Unraveling these mysteries will be a major focus of personalized medicine in the coming decades. Where did SARS-CoV-2 come from? This means it may be able to cause more damage than viruses we come across often, like the flu or common cold. Bats are unique. acute respiratory syndrome (SARS). The COVID pandemic, for instance, has shown us that some people may have a genetic predisposition to severe disease while others do not. In one such study, researchers looked for nine kinds of paramyxoviruses in Australian bats over several months by placing plastic sheets beneath roosts and sampling the urine. Published online: 16-October-2020. Rabies. But it's actually not simple. The American Council on Science and Health is a research and education organization operating under Section 501(c)(3) of the Internal Revenue Code. What is it about bats that makes them host to so many virulent viruses? Coronaviruses are zoonotic diseases, meaning they jump from animals to humans. The natural reservoir for Sars-CoV-2 is thought to be bats, and though Shi said the virus was most probably passed on … "All nine have demonstrated the ability to enter human cells via the ACE2 receptor and can replicate in human epithelial cells. Indeed, they are often asymptomatic. But they also seem to be the mammal that hosts the greatest number of highly virulent viruses that can infect humans. "It is not random that a lot of these viruses are coming from bats." Why are bats, more than other mammals, a reservoir of virulent zoonotic diseases? Jefferies Healthcare Research teams in Japan, the US, Europe, and Australia did a deep dive into the threats of future pandemics for clients and their implications in the biotech industry. Helping Smokers Quit: The Science Behind Tobacco Harm Reduction, Foods Are Not Cigarettes: Why Tobacco Lawsuits Are Not a Model for Obesity Lawsuits, The Prevention and Treatment of Osteoporosis: A Review. 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